An Integrated Approach to Metabolomics Studies: Discovery to Quantitation on a Single Platform

Introduction Cellular metabolomics is an important area of study providing valuable insights into changes associated with biochemical reactions and metabolic pathways. Analyzing the metabolic activities of cells has allowed better understanding of intricate cellular processes involved in cancer progression and drug responses. Therefore, the characterization of cancer cell-specific metabolome signatures would provide beneficial information for early diagnosis of cancer and therapeutic cancer research. Mass spectrometry (MS)-based metabolomics has proven to be advantageous in investigating the metabolic profiles of cancer cells. A wealth of information, including the biochemical phenotypes, molecular mechanisms of cancer development, response, and resistance against drug therapy, can all be obtained using mass spectrometry.